DBP2 — Neurospora crassa

Summary

NCU11175 (DBP2, NcDBP2) on Neurospora crassa chromosome 3 encodes a DEAD-box RNA helicase with RNA helicase activity, RNA binding, ATP hydrolase activity, and ATP binding (EC 3.6.4.13). The gene is associated with gene expression, ribosomal large subunit assembly, RNA splicing, mRNA processing, ribosome biogenesis, and rRNA processing. It is linked to fruiting body formation and localizes to the preribosome large subunit precursor, nucleolus, and cytosol. Phenotypic associations include abnormal mitotic recombination, decreased mating type switching, absent sporulation efficiency, altered chemical resistance, increased thermotolerance, increased gamma ray resistance, delayed vegetative growth, increased sporulation, increased carbon source utilization, and cell cycle progression abnormalities including delayed G2/M phase transition and increased S phase rate. Related genes in other species link the family to oxidative stress response.