MEC1 — Neurospora crassa

Summary

NCU11188 (MEC1, also known as mus-9 or RAD3) on Neurospora crassa chromosome 1 encodes a protein serine/threonine kinase with histone H2A kinase activity, belonging to the PI3/4-kinase family and containing HEAT, FAT, and FATC domains. The gene is associated with DNA damage response signal transduction, regulation of double-strand break repair, meiotic and mitotic DNA damage checkpoints, reciprocal meiotic recombination, telomere maintenance via recombination, and regulation of autophagy. It is linked to the ATR-ATRIP complex and localises to the nucleus, nucleolus, chromatin, and telomeric chromosome regions. Phenotypic associations include abnormal colony size, absent X-ray resistance, altered cell cycle progression rates, increased sporulation rate, increased thermotolerance, and abnormal mitotic recombination. The gene is also associated with respiration rate.