GCN5 — Neurospora crassa

Summary

NCU10847 (symbol GCN5, also known as ngf-1 and NcGCNE) on Neurospora crassa chromosome 1 encodes a protein with GNAT and bromodomain family features. The enzyme exhibits histone H3K18, H3K9, H3K14 acetyltransferase activities, histone crotonyltransferase activity, and acts as a reader of H4K16ac, H4K12ac and H3K56ac marks. It is associated with promoter-specific chromatin binding, transcriptional co-regulator activity, chromatin adaptor activity, and transcription coactivator activity. It localises to the nucleus, chromatin, centromere complex, and the ADA, SALSA and SWR-C complexes. The gene is associated with blue light response, nonsense-mediated mRNA decay, DNA repair-dependent chromatin remodelling, positive regulation of transcription elongation by RNA polymerase II, and cellular response to xenobiotic stimulus. Phenotypic associations include increased sporulation rate, increased nutrient uptake, altered mitophagy, increased transposable element transposition, and abnormal chronological lifespan. Related genes in other species link the family to virulence, oxidative stress response, and potassium and phosphate content.