FHPA — Neurospora crassa

Summary

NCU10051 (FHPA) on Neurospora crassa chromosome 7 encodes a nitric oxide dioxygenase [NAD(P)H] activity (EC 1.14.12.17) and belongs to the globin and flavoprotein pyridine nucleotide cytochrome reductase families, with FAD, heme, and oxygen binding. The gene is associated with nitric oxide breakdown, alternative respiration, cellular response to nitrosative stress, detoxification, gluconeogenesis, heterotrophy, and filamentous growth. It localises to mitochondria, cytoplasm, cytosol, and nucleus. Phenotypic associations include decreased fermentative and respiratory metabolism, increased pheromone sensitivity and mating response, abnormal budding and endomembrane morphology, increased flocculation and autophagy, decreased gamma ray and freeze-thaw resistance, increased hyperosmotic stress resistance, absent pseudohyphal growth, G1 and G2/M cell cycle arrest, decreased stationary phase survival, increased mitotic recombination and telomere length, and absent vegetative growth under certain conditions. Related genes in other species link the family to oxidative stress response and reduced virulence.