MRH1 — Neurospora crassa

Summary

NCU10055 (MRH1, also known as nop-1) in Neurospora crassa encodes a rhodopsin-family protein with a rhodopsin retinal-binding site and archaeal/bacterial/fungal rhodopsin domain. The product binds trans retinal, exhibits monoatomic ion channel activity and photoreceptor activity, and localises to the ER, plasmalemma and membranes. It is associated with retinal isomerisation, phototaxis, phototransduction, response to light stimulus, carotenoid metabolism, osmolarity sensing, carbohydrate utilisation, mannitol anabolism, glucose metabolism, cellulose breakdown, TCA cycle, secondary metabolism, asexual sporulation, spore germination, sexual reproduction, cell differentiation and structural organisation. The gene is associated with increased thermotolerance, anaerobic growth, freeze-thaw resistance and starvation resistance, as well as abnormal colony colour, cell cycle arrest, altered spindle morphology, and changes in cell death, adhesion, prion inheritance and silencing.