ABCA — Neurospora crassa

Summary

NCU10009 (ABCA, NcABCA) encodes an ATP-binding cassette (ABC) transporter, possessing ATP hydrolase activity and ATP-coupled transmembrane transporter activity. The gene is associated with ceramide, ergosterol, phospholipid, and chitin anabolism, as well as xenobiotic detoxification via transmembrane export across the plasma membrane and response to antibiotics. Its product localizes to the plasma membrane. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, delayed exit from G0, increased fermentative growth, abnormal replicative and chronological lifespan, decreased utilization of sulfur sources, and abnormal pseudohyphal growth. Studies of related genes in other species link the family to traits such as plant height, root length, drought tolerance, and oxidative stress response.