ABCA — Neurospora crassa

Summary

NCU09830, designated NcABCA and also known as mig-12, encodes an ABC-type xenobiotic transporter with ATP hydrolase activity and ATP binding. In Neurospora crassa, this gene is associated with ceramide, phospholipid, chitin, and ergosterol anabolism, as well as ergosterol metabolism, cellular monoatomic cation homeostasis, and detoxification processes including response to antibiotics and xenobiotic stimuli. It localizes to the plasma membrane and is linked to xenobiotic detoxification by transmembrane export. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death, delayed mitophagy, altered replicative and chronological lifespan, and defects in cell fusion, endocytosis, and pseudohyphal growth. Studies of related genes in other species link the family to multidrug resistance and vacuolar transport.