ACUF — Neurospora crassa

Summary

NCU09873 (ACUF, acu-6) on Neurospora crassa chromosome 6 encodes a phosphoenolpyruvate carboxykinase (ATP) (EC 4.1.1.49) and contains PEP_carboxykinase_N, PEP_carboxykinase_C, PEPCK_ATP_CS and PEP_carboxykinase_ATP domains. The gene is associated with gluconeogenesis, the glyoxylate cycle, acetate metabolism, the TCA cycle, alternative respiration, heterotrophy and detoxification. It localises to the cytosol and cell-bound compartments. Phenotypic associations include absent anaerobic growth and filamentous growth, increased resistance to hydrostatic pressure, alkaline pH and ionic stress, decreased chemical excretion and nutrient uptake, abnormal colony shape, septum formation, cell size and nuclear transport, increased entry into G0 phase, premature cell cycle progression through metaphase and telophase, increased meiotic recombination, decreased mitochondrial rho- mutation frequency, and absent mating response and cytokinesis. Studies of related genes in other species link the family to carbon source utilisation.