MEP1 — Neurospora crassa

Summary

NCU09859 (MEP1) on Neurospora crassa chromosome 6 encodes a metallopeptidase belonging to the Peptidase_M43 family, with metallopeptidase activity and metal binding. This extracellular protein is associated with proteolysis and evasion of symbiont recognition by host pattern recognition receptors. Studies of related genes in other species link the MEP1 family to effector functions, including both cytoplasmic and apoplastic effectors, and to reduced virulence. The family has also been connected to respiratory disease.