KLP3 — Neurospora crassa

Summary

NCU09730, symbol KLP3 (also known as kin-1 or NcKLP3) in Neurospora crassa on chromosome 4, encodes a kinesin-like protein with a kinesin motor domain and ATP hydrolase activity. The product possesses microtubule motor activity, including both minus-end-directed and plus-end-directed microtubule motor activity, as well as microtubule binding and lateral binding. This gene is associated with numerous microtubule-based processes, including mitotic anaphase spindle elongation, meiotic spindle assembly, mitotic spindle midzone assembly, and initial mitotic spindle pole body separation. It is also linked to chromosome movement to the spindle pole, kinetochore retrieval, plus-end-directed chromosome gliding, and protein transport along microtubules to the kinetochore. Additional associations include retrograde transport and vesicle recycling within the Golgi, mitochondrion distribution, and nucleus localization. The protein localizes to polar microtubules, the plus-end kinesin complex, kinesin I complex, and mitotic and meiotic spindles.