ADB — Neurospora crassa

Summary

NCU09789 (ADB, ad-8) on Neurospora crassa chromosome 6 encodes an adenylosuccinate synthetase, a P-loop NTPase family enzyme with adenylosuccinate synthase activity (EC 6.3.4.4) that binds GMP, AMP, GTP and magnesium. The gene is associated with de novo AMP biosynthesis and IMP metabolism, as well as cellular response to cadmium, DNA damage tolerance, bypass DNA synthesis, DNA repair, mating, and protein synthesis. It localises to the cytoplasm. Phenotypic associations include abnormal cell cycle progression, increased filamentous growth and sporulation efficiency, decreased UV resistance, decreased alkaline pH and hydrostatic pressure resistance, decreased respiratory growth, auxotrophy, altered carbon and nitrogen source utilisation, abnormal nuclear and nucleolar morphology, decreased prion formation and silencing, and increased metal resistance. Related genes in other species are linked to reduced virulence and altered spore germination.