RAD6 — Neurospora crassa

Summary

NCU09731 (RAD6, mus-8) on Neurospora crassa chromosome 4 encodes a ubiquitin-conjugating enzyme (EC 2.3.2.23) with ubiquitin-protein transferase activity, ssDNA-dependent ATPase activity, ssDNA binding, ATP binding, and proteasome binding. The gene is associated with spermatogenesis, pachytene, meiotic DNA double-strand break formation, error-free translesion synthesis, the N-end rule pathway of ubiquitin-dependent protein breakdown, mitotic G1 DNA damage checkpoint, response to UV and UV-A, cellular response to unfolded protein, epigenetic regulation of gene expression, co-transcriptional chromatin reassembly, negative regulation of the SREBP signaling pathway, and regulation of dipeptide transport. It localizes to heterochromatin, telomeric regions, the cytoplasm, nucleus, and fungal biofilm matrix. Phenotypic associations include abnormal cell cycle progression, pheromone sensitivity, mitotic recombination, transposable element transposition, nuclear export, endocytosis, mitophagy, and chronological lifespan.