cys-14 — Neurospora crassa

Summary

NCU09642, symbol cys-14 on Neurospora crassa chromosome 4, encodes a high-affinity sulfate transporter belonging to the SLC26A/SulP family and possesses sulphate porter and sulphate transporter activities. The gene is associated with sulfate import into the cell, sulphate transport, chloride transmembrane transport, and membrane transport. Its product localises to the plasmalemma, endoplasmic reticulum, and fungal-type vacuole membrane. Cys-14 is associated with decreased pheromone sensitivity, increased desiccation resistance, increased chronological lifespan, altered oxidative stress resistance, decreased hyperosmotic stress resistance, increased heat sensitivity, decreased vegetative growth, abnormal vacuolar morphology, and altered competitive fitness. Studies of related genes in other species connect the family to decreased chronological lifespan.