fmf-1 — Neurospora crassa

Summary

NCU09387, designated fmf-1 on Neurospora crassa chromosome 1, encodes a protein containing an HMG-box domain and belonging to the SOX/SOX-like transcription factor family. The product exhibits RNA polymerase II-specific DNA-binding transcription factor activity, functioning as both a transcriptional activator and repressor, and binds and bends cis-regulatory regions. This gene is associated with pheromone response, mating, ascospore formation, and meiosis, as well as the regulation of transcription by RNA polymerase II. The protein localises to the nucleus, cytoplasm, and the Tor2-Mei2-Ste11 complex.