NMT1 — Neurospora crassa

Summary

NCU09345, designated NMT1 (nmt-1) on Neurospora crassa chromosome 2, encodes a protein of the NMT1/THI5 and SsuA/THI5 domain families. The product possesses 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP, along with transferase activity and metal binding. This gene is associated with thiamin anabolism, TPP metabolism and biosynthesis, as well as ergothioneine and selenoneine anabolism. Additional associations include RNA splicing, translation initiation, and cell growth. The protein localizes to both the cytosol and nucleus. Studies of related genes in other species link the NMT1 family to decreased sporulation, altered chemical compound accumulation, abnormal vacuolar morphology, reduced vegetative growth and competitive fitness, decreased chemical resistance, and haploinsufficiency.