PAB1 — Neurospora crassa

Summary

NCU09377, also known as PAB1, rgb-1, CDC55, NcPAB1, or NcCDC55 in Neurospora crassa on chromosome 1, encodes a protein with protein phosphatase activator and regulator activities, belonging to the PP2A_PR55 family and containing WD40 repeats. This gene is associated with numerous biological processes including achiasmate meiosis I, cellular hyperosmotic salinity response, mitotic G2/M transition checkpoint, microautophagy, asexual reproduction, hyphal growth, and translation initiation. It localizes to the PP2A complex, mitotic spindle, spindle pole body, fungal-type vacuole membrane, cytosol, and nucleus. Phenotypic associations include absent sporulation efficiency, increased thermotolerance, increased polyploidy rate, delayed carbon source utilization, decreased septum formation, abnormal pheromone production, and absent cell fusion. Studies of related genes in other species link the family to germination rate and salt tolerance.