CMK2 — Neurospora crassa

Summary

NCU09212 (CMK2, also known as RCK1, SRK1, or camk-4) on Neurospora crassa chromosome 1 encodes a protein with calcium/calmodulin-dependent kinase, protein kinase A, and histone H3S10 kinase activities, and binds calmodulin and ATP. The product is associated with multiple cell cycle processes, including regulation of mitotic spindle assembly, the spindle assembly checkpoint, sister chromatid segregation, and meiotic checkpoints, as well as chromosome segregation during meiosis II. It is linked to negative regulation of calcineurin-mediated signaling and protein import into the nucleus, and to upregulation of spore germination and ergothioneine anabolism. Phenotypic associations include altered cell cycle progression, increased polyploidy, abnormal nucleophagy, increased endocytosis, and absent resistance to osmotic stress, UV, and desiccation. The protein localizes to the kinetochore microtubule, spindle midzone, and CPC complex.