FHL1 — Neurospora crassa

Summary

NCU09309 (FHL1, also known as pcb-5) in Neurospora crassa encodes a proteasome subunit beta-type protein with threonine endopeptidase activity (EC 3.4.25.1). The gene is associated with 20S proteasome assembly, proteasomal protein catabolic processes, the glyoxylate cycle, penicillin anabolism, detoxification, signal transduction, and mating, including detection of pheromone. Its product localises to the proteasome core complex, peroxisome, nuclear envelope, cytoplasm, cytosol, and nucleus. FHL1 is linked to protein content, and to phenotypes including altered cell cycle progression, abnormal shmoo formation, increased pheromone sensitivity, altered UV resistance, increased mutation frequency, abnormal silencing, and abnormal peroxisomal and Golgi distribution. Studies of related genes in other species connect the family to turgor pressure and to human homologs including PBA1 and ADD66.