DBP2 — Neurospora crassa

Summary

NCU09076 (DBP2, NcDBP2) on Neurospora crassa chromosome 1 encodes an ATP-dependent RNA helicase SUB2 with RNA helicase activity, mRNA binding, identical protein binding, hydrolase activity, RNA binding, ATP hydrolase activity, and ATP binding. It is associated with mRNA-nucleus export, TC-NER, mRNA 3'-end processing, RNA splicing, RNA elongation from Pol II promoter, mRNA transport, telomeric silencing, mRNA splicing via spliceosome, mRNA processing, ribosome biogenesis, and fruiting body formation. The product localizes to the TREX complex, spliceosome complex, and chromosome telomeric region. Phenotypic associations include abnormal mitotic recombination, decreased mating type switching, absent sporulation efficiency, altered chemical resistance, increased thermotolerance, increased gamma ray resistance, delayed vegetative growth, increased sporulation, increased carbon source utilization, and increased fermentative growth. Cell cycle associations include increased rate of G1/S and S phase progression, delayed G2/M transition, and delayed or arrested anaphase progression.