NPKA — Neurospora crassa

Summary

NCU09123 (NPKA) of Neurospora crassa on chromosome 1 encodes a protein with a protein kinase domain, serine/threonine kinase active site, and kinase-like domain superfamily, and has calcium/calmodulin-dependent kinase activity, protein kinase A activity, ATP binding, and identical protein binding activities. The gene is associated with the positive and negative regulation of pseudohyphal growth, regulation of invasive growth in response to glucose limitation, and single-species surface biofilm formation. It is linked to meiotic processes including positive regulation of reciprocal meiotic recombination, the pachytene checkpoint, and upregulation of premeiotic DNA replication initiation. NPKA is also connected to downregulation of protein localisation to nucleus, negative regulation of calcineurin-mediated signaling, and cellular response to Ca2+ ions. Localisation evidence places the product at the linear element, ascus epiplasm, perinuclear space, and septin ring structures.