NDE1 — Neurospora crassa

Summary

NCU08980, designated NDE1 (also known as nde-2) on Neurospora crassa chromosome 3, encodes a non-electrogenic NADH dehydrogenase (quinone) (EC 1.6.5.9) with FAD/NAD-binding domains, localised to the mitochondrial inner membrane and lumen. This enzyme is associated with oxidative phosphorylation from NADH to ubiquinone, cellular respiration, and spore germination. Phenotypic associations link NDE1 to cell cycle progression, including G2/M phase transition and M phase arrest, as well as abnormal colony colour, decreased filamentous growth, increased cell death, and altered mitochondrial transport. The gene is also connected to decreased anaerobic and fermentative growth, abnormal septum formation, increased polyploidy, and reduced nutrient uptake. Related genes in other species associate NDE1 with magnesium content traits.