UVE1 — Neurospora crassa

Summary

NCU08850 (UVE1, also known as mus-18) on Neurospora crassa chromosome 5 encodes a protein with a xylose isomerase-like superfamily domain and exhibits deoxyribonuclease (pyrimidine dimer) activity, endonuclease activity, and heteroduplex DNA loop binding, classifying it as a hydrolase (EC 3.-.-.-). The gene is associated with pyrimidine dimer repair, response to UV, mitochondrial DNA repair, and the UVER pathway, as well as broader DNA repair processes including BER, MMR, and NER. It has been linked to mating and methylation. The product localizes to the mitochondrial chromosome, mitochondria, and nucleus. Related genes in other species are associated with UV-damage endonuclease activity.