ads-1 — Neurospora crassa

Summary

NCU08899 (ads-1) on Neurospora crassa chromosome 5 encodes a Zn2Cys6 DNA-binding domain-containing transcription factor with RNA polymerase II-specific transcription factor activity, DNA binding, and zinc binding functions. The product is a member of the secondary metabolite regulator and transcription factor domain families, localises to the nucleus, and is associated with ergosterol metabolism and anabolism, positive regulation of metabolism, and DNA-dependent transcription. The gene is also linked to the related proteins CDR4 and MDR1. Studies of related genes in other species connect the family to unaffected pathogenicity, as well as to interactions with plant pathogens such as Verticillium dahliae and Fusarium oxysporum, though these associations are not established for N. crassa itself.