bdp-1 — Neurospora crassa

Summary

NCU08809 (bdp-1) on Neurospora crassa chromosome 4 encodes a protein with bromodomain and BTB/POZ domains that is annotated as a histone reader and acetyltransferase, with activities including histone H3K14, H3K9, H3K18, and H4K16ac reader activity, as well as histone crotonyltransferase activity. The gene is associated with heterochromatin boundary formation, DNA repair-dependent chromatin remodeling, positive regulation of transcription elongation by RNA polymerase II, and chromatin silencing. Its product localizes to multiple chromatin-associated complexes including SAGA, ADA, SALSA, and SWR-C, as well as centric heterochromatin and the cytoplasm. Bdp-1 is linked to regulation of DNA-templated transcription, cellular response to xenobiotic stimulus, and methylation. Studies of related genes in other species connect this gene family to altered virulence, with both increased and reduced virulence reported.