GAL1 — Neurospora crassa

Summary

NCU08687 (GAL1) on Neurospora crassa chromosome 4 encodes a galactokinase (EC 2.7.1.6), a member of the GHMP kinase family with galactokinase and ATP-binding activity. The gene is associated with the Leloir pathway, galactose and lactose metabolism, sterol anabolism, syngamy, mating, and upregulation of transcription by galactose. Its product localises to the cytoplasm and cytosol. Phenotypic associations include altered carbon source utilisation, absent or increased fermentative growth, absent mating-type switching, increased hydrostatic pressure and UV resistance, decreased adhesion, absent spore germination, increased entry into G0, abnormal chromosome segregation, cytokinesis and redox state, and altered respiratory metabolism. Studies of related genes in other species link the family to galactose utilisation pathways.