ERG24 — Neurospora crassa

Summary

NCU08762, symbol ERG24 and also known as erg-3 in Neurospora crassa, encodes a D14-sterol reductase with sterol_reductase_CS and ERG24_DHCR-like domains, exhibiting 1.3.1.70 enzyme activity and NADP binding. This gene is associated with ergosterol and sterol anabolism, ceramide anabolism, circadian rhythm, dephosphorylation, NO storage, filamentous growth in response to biotic stimulus, cellular response to xenobiotic stimulus, hypersensitivity, methylation, and homeostasis. The product localises to the ER membrane. ERG24 is linked to numerous phenotypes including abnormal plasma membrane morphology, vacuolar transport, autophagy, cell cycle progression, mating response, and nutrient uptake, as well as decreased spore germination, invasive growth, and vegetative growth arrest. Studies of related genes in other species connect the family to sterol C14-reductase function and traits such as phosphate content, acid sensitivity, and oxidative stress response.