BCR1 — Neurospora crassa

Summary

NCU08807 (BCR1, cre-1) on Neurospora crassa chromosome 4 encodes a transcription factor of the creA/MIG family. The product has DNA-binding transcription factor activity and binds RNA polymerase II cis-regulatory regions and zinc. The gene is associated with carbon catabolite repression, regulation of cellulose and polysaccharide breakdown, response to furfural, regulation of glycogen and glucose metabolism, spore germination, protein secretion, and heterotrophy. It localises to both cytoplasm and nucleus. Phenotypic associations include absent spindle morphology and chromosome segregation, increased sporulation, arrested cell cycle progression in G2 and metaphase, abnormal pseudohyphal growth, decreased UV resistance and nitrogen utilisation, and altered autophagy, adhesion, and protein secretion. Studies of related genes in other species link the family to sugar content, germination rate, acid sensitivity, and oxidative stress response.