phr — Neurospora crassa

Summary

NCU08626, also known as phr or NcPHR1 on Neurospora crassa chromosome 1, encodes a DNA photolyase with CPD photolyase activity (EC 4.1.99.3), binding FAD and damaged DNA. This gene is associated with photoreactive repair, blue light response, phototropism, circadian rhythm and photoentrainment, carotenoid anabolism, signal transduction, stress response, and secretion. It is linked to quantum yield and localizes to the nucleus, cytoplasm, and mitochondria. Studies of related genes in other species connect the family to decreased UV resistance, altered heat and oxidative stress sensitivity, reduced vegetative growth, and changes in competitive fitness and carbon source utilization, though these phenotypes are not established for N. crassa.