qde-3 — Neurospora crassa

Summary

NCU08598, symbol qde-3 on Neurospora crassa chromosome 1, encodes a RecQ-family DNA helicase with ATP-dependent DNA/RNA helicase domains, a zinc-binding domain, and an RQC domain. The enzyme has been annotated with G-quadruplex binding, four-way junction helicase activity, 3'-5' DNA helicase activity, RNA helicase activity, and snoRNA and mRNA binding. The gene is associated with post-transcriptional gene silencing (PTGS), resolution of mitotic recombination intermediates, replication fork arrest and processing, DNA double-strand break processing, recombinational repair, nonsense-mediated mRNA decay, telomere maintenance via recombination, and the intra-S DNA damage checkpoint. It localises to the RecQ helicase-Topo III complex, nuclear replication forks, sites of double-strand breaks, nucleoli, and telomeric repeat regions.