AC1 — Neurospora crassa

Summary

NCU08377 (cr-1, AC1) of Neurospora crassa on chromosome 1 encodes a protein with adenylyl cyclase activity (EC 4.6.1.1) and MAP kinase serine/threonine phosphatase activity, containing adenylate cyclase and nucleotide cyclase domains. It is associated with cAMP and cGMP metabolism, bioluminescence, gluconeogenesis, the TCA cycle, cellulose breakdown, hyphal growth, fungal-type cell wall organization, protein secretion, intracellular signal transduction, and the glucose-sensing PKA pathway. The protein localizes to the plasmalemma, cytoplasm, and nucleus. Phenotypic associations include abnormal spore germination, pheromone sensitivity, and filamentous growth; increased necrotic cell death, adhesion, and fermentative growth; decreased lifespan and entry into G0; and absent desiccation and hyperosmotic stress resistance. Studies of related genes in other species link the family to loss of pathogenicity and cell cycle arrest.