BUD6 — Neurospora crassa

Summary

NCU08468 (BUD6) in Neurospora crassa encodes a cytoskeletal regulatory protein that binds actin and is a member of the AIP3/Bud6 family, containing AIP3_C and Aip3p_Bud6_N domains. The gene is associated with actin nucleation, cell polarization, morphogenesis, exocytosis, cytokinesis, and cell growth. Its product localizes to the actin cap, cell tip, cell division site, and cytoplasm. BUD6 is associated with abnormal bipolar budding, delayed cytokinesis and protein secretion, decreased budding and intracellular transport, absent cell fusion, abnormal filamentous growth, altered redox state, and aberrant prion inheritance and formation. It is also linked to premature G2/M transition and increased metaphase duration, as well as decreased micronucleophagy and nucleophagy.