FLBA — Neurospora crassa

Summary

NCU08319 (FLBA) on Neurospora crassa chromosome 4 encodes a developmental regulator flbA variant with GTPase-activating protein (GAP) activity, containing RGS and DEP domains. The gene is associated with negative regulation of GPCR signaling, downregulation of signal transduction, and sterigmatocystin breakdown. It has been connected to regulation of conidium formation, asexual sporulation, carbon catabolite repression, the pheromone response MAPK cascade, and secondary metabolite biosynthesis. The product localizes to the cytoplasm, nucleus, and internal side of the plasma membrane. Phenotypic associations include abnormal mating response, altered pheromone sensitivity and shmoo formation, increased chemical compound excretion, decreased cell fusion, and absent osmotic stress resistance. Studies of related genes in other species link the family to germination rate and oxidative stress response.