URA1 — Neurospora crassa

Summary

NCU08287 (URA1, pyr-3) on Neurospora crassa chromosome 4 encodes a protein with aspartate carbamoyltransferase activity (EC 2.1.3.2), carbamoyl-phosphate synthase activity (EC 6.3.5.5, EC 6.3.4.16), and glutaminase activity (EC 3.5.1.2), and it binds ATP, amino acids, and metals. The gene is associated with pyrimidine and arginine biosynthesis, including de novo UMP biosynthesis, the urea cycle, and glutamine metabolism. It localizes to the cytoplasm, cytosol, nucleus, mitochondria, and the carbamoyl-phosphate synthase complex. URA1 is linked to numerous cellular phenotypes, including abnormal cell cycle progression, cytokinesis, budding, endocytosis, nuclear export, vacuolar and peroxisomal transport, mitochondrial genome maintenance, prion formation and loss, colony shape, nitrogen source utilization, and respiratory metabolism. Studies of related genes in other species connect the family to oxidative stress response and anaerobic growth.