cdt-2 — Neurospora crassa

Summary

NCU08114 (cdt-2) on Neurospora crassa chromosome 1 encodes a major facilitator superfamily (MFS) sugar transporter with D-glucose transmembrane transporter activity and proton:sugar symporter activity. The gene is associated with cellobiose transport, glucose transmembrane transport, carbohydrate transport, and both cellulose and lignin breakdown. It is linked to filamentous growth, including responses to heat and neutral pH, as well as fermentation, secretion, endocytosis, and cellular responses to xenobiotic stimuli and neutral pH. The product localises to the plasma membrane, membrane, and extracellular vesicles. Studies of related genes in other species, including hexose transporters and the lactose permease LAC12, connect the family to broader sugar uptake and catabolism.