DSPC — Neurospora crassa

Summary

NCU08158, designated NcDSPC on Neurospora crassa chromosome 7, encodes a protein-tyrosine-phosphatase with dual-specificity phosphatase catalytic domain and protein tyrosine/serine/threonine phosphatase activity (EC 3.1.3.48). The gene is associated with cytosolic large ribosomal subunit assembly, ribosome assembly, mitochondrial translation, electron transport chain, and signaling. Its product localises to the cytosol and nucleus. NcDSPC has been linked to numerous phenotypes including delayed sporulation, cell cycle progression, and endocytosis; altered vegetative growth (both arrested and increased); increased desiccation, ionic, and hyperosmotic stress resistance; decreased critical cell size at G1; abnormal spore wall formation, cytoskeleton morphology, and nuclear position; and altered RNA and protein accumulation and modification. Studies of related genes in other species connect the family to meiosis, acid pH resistance, and oxidative stress response.