DCL1 — Neurospora crassa

Summary

NCU08270, symbol DCL1 (also known as dcl-1, DCR1, NcDCL1, NcDCR1) on Neurospora crassa chromosome 4, encodes a protein with ribonuclease III and helicase activities, containing domains including Dicer dimerisation, PAZ, RNase_III, and helicase motifs. It is associated with siRNA processing, antiviral response, regulation of antiviral response, and response to virus, as well as meiosis. The protein localises to both the cytoplasm and nucleus. Related genes in other species link the DCL1 family to similar RNA interference and antiviral functions.