ERG5 — Neurospora crassa

Summary

NCU08197 (ERG5) on Neurospora crassa chromosome 3 encodes a cytochrome P450 2E1 protein belonging to the fungal cytochrome P450 family, with monooxygenase activity, heme and iron binding, and oxidoreductase activity acting on paired donors with oxygen incorporation. The gene is associated with ergosterol, terpenoid, mycotoxin, antibiotic, and hormone anabolism, as well as small molecule biosynthesis. It is linked to membrane localisation and hypersensitivity. Phenotypic associations include increased fermentative growth rate, decreased endocytosis, absent micronucleophagy, abnormal telomere length and plasma membrane morphology, absent vacuolar transport, decreased meiosis, abnormal autophagy, decreased shmoo formation and mating response, increased budding and cell death, decreased colony size and cytokinesis, arrested vegetative growth and cell cycle progression, delayed G2/M transition, abnormal cytoskeleton and mitochondrial distribution, decreased nutrient uptake and mitochondrial genome maintenance, and petite phenotype.