ABCA — Neurospora crassa

Summary

NCU08056 (ABCA, NcABCA) on Neurospora crassa chromosome 1 encodes the ABC multidrug transporter atrF, a member of the ABCG/PDR family with ATP-binding and hydrolase activities. The gene is associated with ABC-type xenobiotic transporter activity and ATP-coupled transmembrane transport, and its product localises to the plasma membrane. It is linked to detoxification, response to antibiotics and xenobiotic stimuli, and transmembrane export of xenobiotics. Annotated associations include ceramide, ergosterol, phospholipid and chitin anabolism, cellular cation homeostasis, and hypersensitivity. Phenotypic connections involve abnormal small molecule transport, increased sporulation rate, altered vacuolar distribution and transport, decreased cell death, delayed mitophagy, and abnormal cell cycle progression, pseudohyphal growth, and chronological lifespan.