CHO2 — Neurospora crassa
Summary
NcCHO2 (NCU08045) on Neurospora crassa chromosome 4 encodes a phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17), a phospholipid methyltransferase family protein. This gene is associated with phosphatidylcholine anabolism, lipogenesis, lipid metabolism, methylation, circadian rhythm, sporulation, and spore formation. The product localizes to the perinuclear and cortical endoplasmic reticulum membrane. Associations with numerous phenotypes include increased apoptosis rate, decreased spore germination, delayed cell cycle progression, abnormal colony shape, increased X-ray resistance, and altered mitochondrial genome maintenance. Related genes in other species link the family to oxidative stress response.
Annotations
- Chromosome
- 4
- Related genes
- AT1G48600, AT3G18000, CHO2, SET1, LEM3, LRO1, MET17, ARE1
- GO terms
- Phosphatidylethanolamine N-methyltransferase Activity, lipogenesis, ER membrane, Sporulation, Methylation, spore formation, phosphatidylcholine anabolism, perinuclear ER
- Publications
- 28357333, 33513092, 22451923, 22543816, 19398585, 22433850, 22493290, 9315648
- Traits
- RESISTANCE TO CHEMICALS: DECREASED, COMPETITIVE FITNESS: DECREASED, STRESS RESISTANCE: DECREASED, INVIABLE, RESISTANCE TO CHEMICALS: INCREASED, RESISTANCE TO CHEMICALS: NORMAL, CELL SIZE: INCREASED, RESPIRATORY GROWTH: INCREASED