crp-2 — Neurospora crassa

Summary

NCU07830, symbol crp-2, on Neurospora crassa chromosome 3, encodes a structural constituent of the ribosome, belonging to the ribosomal S11 family and the uS11 domain superfamily. The gene is associated with ribosomal small subunit assembly, translation, and cytoplasmic translation, and its product localises to the cytosolic small ribosomal subunit, the nucleolus, stress granules, and the SSU processome, as well as the yeast-form and hyphal cell walls. Annotated phenotypes link crp-2 to cell cycle progression, including delayed mitosis and increased critical cell size at the G1 checkpoint, as well as altered stress responses such as increased starvation and desiccation resistance, decreased cold sensitivity and X-ray resistance, and abnormal cytokinesis. The gene is also associated with mating response, pheromone sensitivity, shmoo formation, and mitochondrial genome maintenance. Related genes in other species link the family to oxidative stress response and acid sensitivity.