AOX — Neurospora crassa

Summary

NCU07953 (AOX, NcAOX) on Neurospora crassa chromosome 4 encodes an alternative oxidase (ALTOX) with alternative oxidase activity and metal binding, belonging to the AOX_sf family. It is localized to the mitochondrial inner membrane and mitochondria. This gene is associated with alternative respiration, the electron transport chain, electron transfer, gluconeogenesis, fermentation, detoxification, heterotrophy, secondary metabolism, hypersensitivity, syngamy, sexual reproduction, mitochondrial translation, ribosome assembly, and protein synthesis. Related genes in other species link the family to oxidative stress response and associations with fungal pathogens including Verticillium dahliae and Fusarium oxysporum.