CYS3 — Neurospora crassa

Summary

NCU07987 (CYS3) on Neurospora crassa chromosome 4 encodes a pyridoxal phosphate-dependent enzyme with O-acetylhomoserine (thiol)-lyase, homocysteine synthase, cysteine-S-conjugate β-lyase and cysteine synthase activities (EC 4.4.1.13). The gene is associated with L-homocysteine and L-methionine biosynthesis, cysteine anabolism, transsulfuration, sulfur metabolism, alkaloid metabolism, sulphate transport, and cell growth. The product localises to the peroxisome, cytoplasm, cytosol and nucleus. CYS3 is linked to numerous phenotypes including abnormal nutrient utilisation and sulfur source utilisation, altered cell cycle progression through G2/M and G1/S checkpoints, increased aneuploidy, increased meiotic recombination, increased UV and X-ray resistance, increased stationary-phase survival, decreased colony size, absent filamentous growth, abnormal nucleophagy and mitophagy, decreased prion inheritance, and altered nutrient uptake. Studies of related genes in other species connect the family to oxidative stress response and virulence.