clr-2 — Neurospora crassa

Summary

NCU08042, symbol clr-2 on Neurospora crassa chromosome 4, encodes a Zn2Cys6 DNA-binding transcription factor that binds RNA polymerase II cis-regulatory regions. The protein belongs to the fungal secondary metabolite regulator family and localises to the nucleus. In N. crassa, clr-2 is associated with the breakdown of cellulose, mannan and polysaccharides, as well as with galactose metabolism, catabolite repression, and the upregulation of transcription by galactose. It is also linked to bioluminescence, sporulation, fermentation, ergosterol anabolism, protein secretion and processing, signal transduction, and regulation of gene expression. Related genes in other species, including Verticillium dahliae and Fusarium oxysporum pathovars, encode Zn(2)-C6 fungal-type transcription factors.