ERG25 — Neurospora crassa

Summary

NCU07910, designated ERG25 on Neurospora crassa chromosome 4, encodes a protein with 4-methylsterol oxidase activity, iron binding, and redox activity. This enzyme is localized to the endoplasmic reticulum membrane and is associated with sterol homeostasis, sterol anabolism, and ergosterol anabolism. The gene is linked to the broader process of homeostasis. Studies of related genes in other species connect the sterol desaturase family to fatty acid hydroxylase domains and similar redox functions, though these associations are not established for N. crassa itself.