DBP2 — Neurospora crassa

Summary

NCU07839 (DBP2) on Neurospora crassa chromosome 3 encodes a DEAD-box RNA helicase with ATP hydrolase activity, RNA helicase activity, and binding capabilities for G-quadruplex DNA, snoRNA, mRNA, and RNA. The gene is associated with alternative mRNA splicing via the spliceosome, nonsense-mediated mRNA decay, nuclear polyadenylation-dependent mRNA catabolism, RNA 3'-end formation, ribosome biogenesis, and rRNA processing. It is linked to fruiting body formation, sporulation efficiency, vegetative growth, cell cycle progression (including G1/S and G2/M transitions, S phase, and anaphase), mitotic recombination, mating type switching, thermotolerance, gamma ray resistance, chemical resistance, chromosome segregation, carbon source utilization, and fermentative growth. The protein localizes to the nucleus, cytoplasm, and ribonucleoprotein complexes. Related genes in other species are linked to oxidative stress response.