ARP1 — Neurospora crassa

Summary

NCU07823 (ARP1, also known as NcARP1 or NcSDH1) on Neurospora crassa chromosome 3 encodes a scytalone dehydratase, a lyase with metal-binding activity that belongs to the scytalone dehydratase and NTF2-like domain superfamilies. The gene is associated with melanin metabolism and anabolism, pigment anabolism, xanthones and monodictyphenone anabolism, secondary metabolite biosynthesis, conidia and spore formation, nuclear movement, and vesicle transport. Its product localises to the endosome. Studies of related genes in other species link the scytalone dehydratase family to loss of pathogenicity and reduced virulence, as well as to plant diseases such as anthracnose and rice blast, though these associations are not established for N. crassa itself.