ZC274 — Neurospora crassa

Summary

NCU07705, also known as ZC274 or clr-1 in Neurospora crassa, encodes a Zn2Cys6 DNA-binding transcription factor with RNA polymerase II-specific activity, containing an EcdB-like regulator domain and a zinc-binding domain. This nuclear protein is associated with the regulation of gene expression, DNA-dependent transcription, and signal transduction. It is associated with cellulose breakdown, secretion, and the HOG response. clr-1 is linked to the CLR-1 gene family, and related genes in other species include sequences from Verticillium dahliae and Fusarium oxysporum. The gene is located on chromosome 4.