sre — Neurospora crassa

Summary

NCU07728, symbol sre, on Neurospora crassa chromosome 4, encodes a GATA transcription factor with iron sensor activity, 2Fe-2S cluster binding, and DNA-binding transcription repressor activity specific to RNA polymerase II. The gene is associated with cellular iron ion homeostasis, regulation of siderophore anabolism, downregulation of ferrichrome anabolism and iron ion transport, and cellular responses to iron, copper, and iron starvation. It is also linked to secretion, hypersensitivity, and oxidative stress response. The product localises to chromatin, cytoplasm, and nucleus. Studies of related genes in other species link the family to reduced virulence, iron concentration, and polysaccharide content, though these associations are not established for N. crassa.