qde-1 — Neurospora crassa

Summary

NCU07534 (qde-1) on Neurospora crassa chromosome 3 encodes an RNA-dependent RNA polymerase (EC 2.7.7.48) with RdRP activity and RNA binding, belonging to the RDRP_core and RNA-dep_RNA_pol_euk-typ domain families. It is associated with post-transcriptional gene silencing (PTGS), siRNA processing, and the RNA-dependent RNA polymerase complex (RDRC). The gene is linked to sexual reproduction processes including oogenesis, spermatogenesis, ascus development, and cell fate determination, as well as defense response, mRNA breakdown, methylation, DNA damage response, DNA replication, mitosis, translation, and regulation of gene expression. Related genes in other species connect the family to similar RNA silencing and defense mechanisms.