MOT1 — Neurospora crassa

Summary

NCU07556, designated MOT1 in Neurospora crassa and located on chromosome 3, encodes a protein with Mot1_central_dom, Mot1_ATP-bd, SNF2/RAD54-like_C, SNF2-like_sf, SNF2_N, Helicase_ATP-bd, Helicase_C, ARM-like, ARM-type_fold, and P-loop_NTPase domains. It is associated with histone octamer slider activity, nucleosome array spacer activity, DNA translocase activity, TBP-class protein binding, ATP-dependent chromatin remodeler activity, centromere binding, histone carrier activity, nucleosome binding, helicase activity, chromatin adaptor, GTF2 activity, histone binding, ssDNA binding, and chromatin binding. MOT1 is associated with regulation of RNA polymerase II transcription preinitiation complex assembly, transposable element silencing, Moco biosynthesis, DNA double-strand break processing, downregulation of heterochromatin organization, nucleosome organization, negative regulation of antisense RNA transcription, cellular pheromone response, nucleosome disassembly, TC-NER, heterochromatin boundary formation, co-transcriptional chromatin reassembly, DNA replication-dependent chromatin assembly, cellular response to copper, CENP-A containing chromatin assembly, rDNA heterochromatin assembly, chlamydospore formation, and RNA 3'-end formation by RNA polymerase II. It is a component of CHRAC, nuclear microtubule, C